Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both <i>in vitro</i> and <i>in vivo</i> models

GO-Y030 holds promise as a potent compound for the systemic inhibition of malignant meningioma. GO-Y030 has higher tumor growth inhibitory effect against meningiomas than curcumin, which is known to have antitumor activity through multi-molecular target control resulting in apoptosis induction. GO-Y030 controls at least three molecules of HGF, nuclear factor kappa B, and N-cadherin.

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Publication Details

Journal
World Journal of Experimental Medicine
Published
2025-04-11
DOI
https://doi.org/10.5493/wjem.v15.i2.102897
Primary Topic
Bone health and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Akihiro Terasawa, Hiroshi Nanjo, Masatomo Miura, Kazuhiro Shimazu et al.
1 links
World Journal of Experimental Medicine
Bone health and treatments
article

Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Akihiro Terasawa, Hiroshi Nanjo, Masatomo Miura, Kazuhiro Shimazu, Hiroyuki Shibata
article en

Abstract

GO-Y030 holds promise as a potent compound for the systemic inhibition of malignant meningioma. GO-Y030 has higher tumor growth inhibitory effect against meningiomas than curcumin, which is known to have antitumor activity through multi-molecular target control resulting in apoptosis induction. GO-Y030 controls at least three molecules of HGF, nuclear factor kappa B, and N-cadherin.

World Journal of Experimental MedicineVol. 15(2)
Akita University (JP)
Good health and well-being
Openalex Percentile: Top 89%
Bone health and treatments
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