Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both <i>in vitro</i> and <i>in vivo</i> models
GO-Y030 holds promise as a potent compound for the systemic inhibition of malignant meningioma. GO-Y030 has higher tumor growth inhibitory effect against meningiomas than curcumin, which is known to have antitumor activity through multi-molecular target control resulting in apoptosis induction. GO-Y030 controls at least three molecules of HGF, nuclear factor kappa B, and N-cadherin.
Authors
- Akihiro Terasawa
- Hiroshi Nanjo (ORCID: https://orcid.org/0000-0002-0885-7151)
- Masatomo Miura (ORCID: https://orcid.org/0000-0001-7120-2425)
- Kazuhiro Shimazu
- Hiroyuki Shibata (ORCID: https://orcid.org/0000-0003-3581-3506)
Institutions
- Akita University (JP)
Publication Details
- Journal
- World Journal of Experimental Medicine
- Published
- 2025-04-11
- DOI
- https://doi.org/10.5493/wjem.v15.i2.102897
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00