Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Glioblastoma cells, residing within a hypoxic microenvironment, exhibit high expression of HIF1α and HIF2α. These transcription factors promote the upregulation of IGF1R, which subsequently activates the PI3K/AKT signaling pathway. This activation, in turn, promotes cell proliferation and chemoresistance, ultimately contributing to tumor malignancy.

Authors

Jie Liu (ORCID: https://orcid.org/0000-0003-3675-1845)
Lu Zhao (ORCID: https://orcid.org/0000-0002-8055-5211)
Bin Liao (ORCID: https://orcid.org/0000-0001-8317-031X)
Pan Wang (ORCID: https://orcid.org/0000-0001-7340-5082)
Nan Wu (ORCID: https://orcid.org/0000-0001-8414-2791)
Sheng Gong

Institutions

Chongqing University (CN)
Chongqing Medical University (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-04-11
DOI: https://doi.org/10.3389/fphar.2025.1575332
Citations: 2
Primary Topic: Cancer, Hypoxia, and Metabolism
Type: article
Field-Weighted Citation Impact: 1.87

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Jie Liu, Lu Zhao, Bin Liao, Pan Wang et al.

Apr 11, 2025

2 citations

Frontiers in Pharmacology

Cancer, Hypoxia, and Metabolism

1.87

article

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

Jie Liu, Lu Zhao, Bin Liao, Pan Wang, Nan Wu, Sheng Gong

April 11, 2025article en

2 citations

Abstract

Glioblastoma cells, residing within a hypoxic microenvironment, exhibit high expression of HIF1α and HIF2α. These transcription factors promote the upregulation of IGF1R, which subsequently activates the PI3K/AKT signaling pathway. This activation, in turn, promotes cell proliferation and chemoresistance, ultimately contributing to tumor malignancy.

Frontiers in PharmacologyVol. 16

Chongqing University (CN), Chongqing Medical University (CN)

Good health and well-being

Openalex Percentile: Top 15%

Cancer, Hypoxia, and Metabolism

1.87

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.