Behavioral and psychological symptoms of dementia and Alzheimer’s disease progression in Down syndrome
BPSD are an important part of AD in DS, particularly during the prodromal stage. Elevated Aβ and NFT predict higher initial avoidance and change in physical depression behaviors and may indicate MCI in adults with DS. Broader increases in BPSD are observed as adults with DS progress from early to late-stage dementia. Clinicians should rule out other possible causes of BPSD when screening for AD, such as stressful life experiences or co-occurring medical conditions. Caregivers of adults with DS should have resources on BPSD management and self-care strategies.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Charles M. Laymon (ORCID: https://orcid.org/0000-0002-5966-7219)
- Sharon J. Krinsky‐McHale (ORCID: https://orcid.org/0000-0002-7205-7319)
- Joseph H. Lee (ORCID: https://orcid.org/0000-0002-2000-4821)
- Christy Hom (ORCID: https://orcid.org/0000-0003-0266-0961)
- Jamie C. Peven (ORCID: https://orcid.org/0000-0002-2187-5514)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- H. Diana Rosas (ORCID: https://orcid.org/0000-0001-9360-7511)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Max McLachlan (ORCID: https://orcid.org/0000-0003-1801-7233)
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Davneet Minhas (ORCID: https://orcid.org/0000-0002-0217-6777)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Alice Lee (ORCID: https://orcid.org/0000-0002-8492-837X)
- Ira T. Lott (ORCID: https://orcid.org/0000-0002-3107-0752)
- Melissa Jenkins (ORCID: https://orcid.org/0000-0002-5805-6053)
- Weiquan Luo
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Annie D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Mark Mapstone
- Lauren Kubic
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- New York State Office for People With Developmental Disabilities (US)
- Massachusetts General Hospital (US)
- VA Pittsburgh Healthcare System (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Journal of Neurodevelopmental Disorders
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s11689-025-09604-w
- Citations
- 3
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development