A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice
A tolerogenic peptide, apitope D121B, reduces T-cell immune responses to Der p 1 and is a promising candidate for further development as an immunotherapy for HDM-associated allergic rhinitis and asthma.
Authors
- David C. Wraith (ORCID: https://orcid.org/0000-0003-2147-5614)
- Lidia de Lucas (ORCID: https://orcid.org/0000-0002-5375-3490)
- Robert West (ORCID: https://orcid.org/0000-0001-7305-3654)
- Mamidipudi Thirumala Krishna (ORCID: https://orcid.org/0000-0003-2109-5777)
- Heather B. Streeter (ORCID: https://orcid.org/0000-0002-3237-2170)
Institutions
- University of Leeds (GB)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1569283
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council