Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation
The SIRT1-related pathway plays a crucial role in regulating angiogenesis and neuroinflammation. Moreover, baicalein exerts a neuroprotective effect against cognitive decline through the SIRT1-mediated Notch1 pathway, which in turn improves angiogenesis and suppresses neuroinflammation.
Authors
- Xiuqin Li (ORCID: https://orcid.org/0000-0001-5885-0807)
- Jingze Liu
- Xiaohua Xie (ORCID: https://orcid.org/0000-0002-0310-4679)
- Meixi Li
- Feng Mo
- Peiyuan Lv (ORCID: https://orcid.org/0000-0001-7259-1266)
- Xiujuan Song (ORCID: https://orcid.org/0000-0002-7800-6256)
- Yu Yin (ORCID: https://orcid.org/0000-0002-0677-095X)
- Jiaxi Song
- Tianjun Wang
- Xiaoli Niu
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Hebei Normal University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fnagi.2025.1521353
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Health Commission of Hebei Province