Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols
Taken together, our results provide a systematic description of cilia in hiPSC-derived neuronal cells generated with different protocols, underscoring the importance of selecting the optimal model system and controls for investigating primary cilia in hiPSC-derived neuronal cells.
Authors
- Melanie Eschment (ORCID: https://orcid.org/0000-0002-6881-6570)
- Martín Müller (ORCID: https://orcid.org/0000-0003-4067-7174)
- Ruxandra Bachmann‐Gagescu (ORCID: https://orcid.org/0000-0002-3571-5271)
- Bronwyn A. Evans (ORCID: https://orcid.org/0000-0001-6161-9956)
- Sally A. Cowley (ORCID: https://orcid.org/0000-0003-0297-6675)
- Joana Figueiro‐Silva (ORCID: https://orcid.org/0000-0003-3590-1784)
- Affef Abidi (ORCID: https://orcid.org/0000-0002-3383-9473)
- David Jackson (ORCID: https://orcid.org/0000-0002-6932-3233)
- Walther Haenseler
- Marta Brasili
- Fee Roethlisberger
Institutions
- University of Zurich (CH)
- FHNW University of Applied Sciences and Arts Northwestern Switzerland (CH)
- Wellcome Centre for Integrative Neuroimaging (GB)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fcell.2025.1516596
- Citations
- 3
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung