Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model
This study provides novel insights into the microstructural abnormalities of the corpus callosum in ASD mouse, supporting the hypothesis that myelination deficits contribute to ASD-related communication impairments between brain hemispheres. However, given the structural focus of this study, further research integrating functional assessments is necessary to establish a direct link between these morphological changes and ASD-related neural dysfunction.
Authors
- Chunying Yin (ORCID: https://orcid.org/0000-0003-4749-2754)
- Peiyao Shi
- Hamza Khan (ORCID: https://orcid.org/0000-0002-0398-4848)
- Jiahao Shi (ORCID: https://orcid.org/0000-0002-6385-2468)
- Ao Cheng (ORCID: https://orcid.org/0000-0002-8106-2187)
- Jiachi Chen (ORCID: https://orcid.org/0000-0002-0192-9992)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-1952-7868)
- Pengcheng Wang (ORCID: https://orcid.org/0000-0002-6154-2482)
- Ruobing Zhang (ORCID: https://orcid.org/0009-0002-5978-7445)
- Jun Guo (ORCID: https://orcid.org/0000-0002-5192-9675)
- Guoqiang Zhao
Institutions
- University of Science and Technology of China (CN)
- Soochow University (CN)
- Suzhou Institute of Biomedical Engineering and Technology (CN)
Publication Details
- Journal
- Frontiers in Neuroinformatics
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fninf.2025.1563799
- Citations
- 2
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86