Protection against N. gonorrhoeae induced by OMV-based meningococcal vaccines are associated with cross-species directed humoral and cellular immune responses
Our findings suggest the cross-protection against gonococcal infection induced by different meningococcal OMV vaccines is likely multifactorial and mediated by different humoral and cellular immune responses induced by these two vaccines.
Authors
- Marguerite B. Little (ORCID: https://orcid.org/0000-0002-9796-9162)
- Margaret C. Bash (ORCID: https://orcid.org/0000-0002-5468-1505)
- Ann E. Jerse (ORCID: https://orcid.org/0000-0002-5118-3172)
- Andrew N. Macintyre (ORCID: https://orcid.org/0000-0002-5297-0207)
- Kathryn Matthias (ORCID: https://orcid.org/0000-0002-6578-1130)
- Aleksandra E. Sikora (ORCID: https://orcid.org/0000-0001-7977-2596)
- Joseph A. Duncan (ORCID: https://orcid.org/0000-0002-4438-2018)
- Kristie L. Connolly (ORCID: https://orcid.org/0000-0002-7516-4427)
- Andreea Waltmann (ORCID: https://orcid.org/0000-0001-9219-6570)
- Keena S. Thomas (ORCID: https://orcid.org/0009-0004-5553-9748)
- Alison K. Criss (ORCID: https://orcid.org/0000-0001-7738-3757)
- Mary C. Gray (ORCID: https://orcid.org/0000-0003-4441-5905)
- Weiyan Zhu (ORCID: https://orcid.org/0009-0005-7855-6329)
Institutions
- University of North Carolina at Chapel Hill (US)
- Oregon State University (US)
- Center for Biologics Evaluation and Research (US)
- Uniformed Services University of the Health Sciences (US)
- Oregon Health & Science University (US)
- Duke University (US)
- Clinical Research Institute (US)
- Children's Cancer Therapy Development Institute (US)
- University of Virginia (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1539795
- Citations
- 4
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 4.73
Funders
- National Institutes of Health