Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis

This study's findings indicate that in T2DM patients with ESRD requiring dialysis, DPP-4i do not elevate the risk of hospitalizations for HF, cardiovascular death, or all-cause mortality, but significantly lower the risk of severe hypoglycemia compared with SUs/meglitinides. This supports the preference for DPP-4i over SUs or meglitinides for managing T2DM in dialysis patients.

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Publication Details

Journal
Pharmacoepidemiology and Drug Safety
Published
2025-04-01
DOI
https://doi.org/10.1002/pds.70138
Citations
2
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
2.59

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article

Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis

Tzu‐Han Lin, Liang‐Yu Lin, Tzu‐Chieh Lin, Yu‐Juei Hsu et al.
2 citations
Pharmacoepidemiology and Drug Safety
Diabetes Treatment and Management
2.59
article

Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis

Tzu‐Han Lin, Liang‐Yu Lin, Tzu‐Chieh Lin, Yu‐Juei Hsu, Ta‐Chuan Hung, Ying‐Jay Liou, Mengting Wang
article en
2 citations

Abstract

This study's findings indicate that in T2DM patients with ESRD requiring dialysis, DPP-4i do not elevate the risk of hospitalizations for HF, cardiovascular death, or all-cause mortality, but significantly lower the risk of severe hypoglycemia compared with SUs/meglitinides. This supports the preference for DPP-4i over SUs or meglitinides for managing T2DM in dialysis patients.

Pharmacoepidemiology and Drug SafetyVol. 34(4)
Tri-Service General Hospital (TW), National Yang Ming Chiao Tung University (TW), Taipei Veterans General Hospital (TW), Tri-Service General Hospital Songshan Branch (TW), National Defense Medical Center (TW)
Shanghai Educational Development Foundation
Good health and well-being
Openalex Percentile: Top 11%
Diabetes Treatment and Management
2.59
DOIOpen Access PDFOpenAlex
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Dipeptidyl Peptidase‐4 Inhibitors and Risk of Heart Failure in Patients With Type 2 Diabetes Mellitus and End‐Stage Renal Disease Requiring Dialysis — Tzu‐Han Lin, Liang‐Yu Lin, et al. · Pharmacoepidemiology and Drug Safety (2025) | TGRS Research Map | TGRS