The Endocannabinoid System Drives Eosinophil Infiltration During Eosinophilic Esophagitis
This study is the first of its kind to investigate the involvement of altered expression of endocannabinoid system components in EoE, and partly explains recent findings of more inflammatory features post EoE-treatment in cannabis users. Our findings could pave the way for research into alternative treatment options for EoE and call for caution regarding the use of cannabinoids in EoE.
Authors
- Anja Pammer (ORCID: https://orcid.org/0000-0002-1778-5567)
- Rudolf Schicho (ORCID: https://orcid.org/0000-0002-5726-4731)
- Julia Konrad (ORCID: https://orcid.org/0009-0002-8454-7363)
- Ulrike Taschler (ORCID: https://orcid.org/0000-0001-9000-1602)
- Oliver Kindler
- Alfred D. Doyle (ORCID: https://orcid.org/0000-0001-9909-0445)
- Dušica Ristić
- Hansjörg Schlager (ORCID: https://orcid.org/0009-0001-7765-3152)
- Dominique Thomas (ORCID: https://orcid.org/0000-0002-4153-3669)
- Julia Kargl (ORCID: https://orcid.org/0000-0002-0870-0816)
- Andreas Blesl (ORCID: https://orcid.org/0000-0002-9338-4140)
- Eva Knuplez (ORCID: https://orcid.org/0000-0001-6376-5842)
- Thomas Bärnthaler (ORCID: https://orcid.org/0000-0002-4988-3700)
- Benjamin L. Wright (ORCID: https://orcid.org/0000-0002-7586-4722)
- Melanie Kienzl (ORCID: https://orcid.org/0000-0001-6508-176X)
- Robert Gurke (ORCID: https://orcid.org/0000-0001-8218-1295)
- Franziska Baumann‐Durchschein
- David Markus Kaspret
- Laura Danner
Institutions
- Goethe University Frankfurt (DE)
- University of Graz (AT)
- Medical University of Graz (AT)
- WinnMed (US)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101515
- Citations
- 2
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Austrian Science Fund