Microbiocenosis of the Cervix and Uterine Cavity in Women with Chronic Cervicitis

Aim. To determine the frequency of chronic endometritis in women with chronic cervicitis and to give a comparative characteristic of the microbiocenosis of the cervix in its isolated inflammation and in combination with the chronic inflammatory process of the uterine mucosa. Design. A prospective comparative study. Materials and methods. The study included 89 women of child-bearing potential with morphologically confirmed chronic cervicitis. All patients underwent a microbiological examination of their cervical canal material (pooled smear microscopy, qualitative and quantitative biomolecular analysis). Endometrial pipelle biopsy was also performed, and biopsy material was sent to morphological and biomolecular analysis. Following bipsy results, all women were divided into two groups: group I — chronic cervicitis without chronic endometritis, isolated type (n = 49); group II — chronic cervicitis with chronic endometritis (n = 40). Results. The frequency of combination of chronic cervicitis with chronic endometritis was 44.9%. There were no statistically significant differences in the species composition of microorganisms in the cervical canal between the groups. Enterococcus spp was more often found in the group of combined inflammatory process. in titles exceeding the threshold values. Enterococcus spp., Leptotrichia amnionii group, Ureaplasma parvum, Streptococcus spp., Ureaplasma urealyticum, and Atopobium vaginae were statistically significantly more often detected in the uterine cavity in patients with concomitant inflammation than in the isolated cervicitis group. Quantitative characteristics of Lactobacillus spp. in the cervical canal in both groups. There was a statistically significant decrease in the amount or absence of Lactobacillus spp in the uterine cavity. in patients with combined inflammatory process. Conclusion. Not all women with morphologically verified chronic cervicitis had chronic endometritis. The study of immune protection factors at the level of the cervix and endometrium will make it possible not only to predict the inflammatory process of the overlying sections, avoiding additional invasive diagnostic interventions, but also to personalize approaches to the treatment of chronic cervicitis. Keywords: chronic cervicitis, microbiocenosis, chronic endometritis.