TMEM158 promotes ICC metastasis via inducing lactic acid mediated reduction of actin skeleton stiffness of ICC cells
TMEM158 reduced the actin skeleton stiffness of ICC cells through activating Ras protein mediated generation of LA, which finally results in enhanced metastasis of ICC. Our work provides a preclinical evidence of concept for TMEM158 as a novel candidate inhibiting the metastasis of ICC.
Authors
- Duguang Li
- Hui Lin (ORCID: https://orcid.org/0000-0001-5459-800X)
- Yiyin Zhang (ORCID: https://orcid.org/0000-0002-4887-2401)
- Cheng Zhong (ORCID: https://orcid.org/0000-0002-9241-2840)
- Peng Chen (ORCID: https://orcid.org/0000-0003-3463-0708)
- Yujie Li (ORCID: https://orcid.org/0000-0002-4115-6226)
- Shengxi Jin (ORCID: https://orcid.org/0009-0002-4524-4642)
- Jing Yang (ORCID: https://orcid.org/0000-0002-3386-2964)
- Xiaoxiao Fan
- Qiming Xia
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.jare.2025.04.003
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- National Key Research and Development Program of China Stem Cell and Translational Research
- Science and Technology Program of Zhejiang Province