ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling
This study reveals the regulatory mechanism of ECM1 in hepatocytes, demonstrating that EGF/STAT1 maintains ECM1 expression to prevent fibrosis, whereas IFNγ/NRF2 signalling inhibits ECM1 during chronic liver inflammation, thereby accelerating disease progression. These findings are important for researchers and clinicians to understand the pathogenesis of liver fibrosis, especially in CLD driven by inflammation or oxidative stress. Clinically, ECM1 levels correlate positively with EGFR expression and negatively with IFNγ/NRF2 activation, providing potential antifibrotic targets for CLD patients.
Authors
- Matthias Glanemann (ORCID: https://orcid.org/0000-0002-5431-6348)
- Chenjun Huang (ORCID: https://orcid.org/0000-0003-3836-6262)
- Shanshan Wang (ORCID: https://orcid.org/0000-0002-5819-9265)
- Roman Liebe (ORCID: https://orcid.org/0000-0002-3199-5595)
- Cyrill Géraud (ORCID: https://orcid.org/0000-0001-9432-6869)
- Matthias Ebert (ORCID: https://orcid.org/0000-0002-0910-0652)
- Frederik Link (ORCID: https://orcid.org/0000-0002-8384-705X)
- Chenhao Tong
- Rilu Feng (ORCID: https://orcid.org/0000-0002-2674-7589)
- Huiguo Ding (ORCID: https://orcid.org/0000-0002-8716-4926)
- Peter ten Dijke (ORCID: https://orcid.org/0000-0002-7234-342X)
- Zeribe C. Nwosu (ORCID: https://orcid.org/0000-0003-1641-2045)
- Chunfang Gao (ORCID: https://orcid.org/0000-0002-4891-2944)
- Weiguo Fan (ORCID: https://orcid.org/0000-0002-2382-5473)
- Claudia Rubie
- Steven Dooley (ORCID: https://orcid.org/0000-0002-4840-6240)
- Christoph Meyer (ORCID: https://orcid.org/0009-0000-6010-300X)
- Weronika Piorońska
- Sai Wang (ORCID: https://orcid.org/0000-0002-9731-3948)
- Lea Berger
- Kerry Gould
- Seddik Hammad (ORCID: https://orcid.org/0000-0003-0571-4208)
- Yujia Li (ORCID: https://orcid.org/0000-0002-1024-9243)
- Chen Shao (ORCID: https://orcid.org/0000-0002-6818-6660)
- Yao Ye (ORCID: https://orcid.org/0000-0002-2187-0211)
- Honglei Weng
- Bing Sun (ORCID: https://orcid.org/0009-0000-1856-2704)
- Laura Kim Feiner
- Hui Liu (ORCID: https://orcid.org/0009-0003-3273-6979)
- Pia Erdösi
Institutions
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Cornell University (US)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Renji Hospital (CN)
- University Hospital Heidelberg (DE)
- Shanghai University of Traditional Chinese Medicine (CN)
- Oncode Institute (NL)
- Essen University Hospital (DE)
- Center for Excellence in Molecular Cell Science (CN)
- Yueyang Hospital (CN)
- European Molecular Biology Laboratory (DE)
- Beijing YouAn Hospital (CN)
- University Medical Centre Mannheim (DE)
- Saarland University (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101423
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung