Clinicopathological features and prognostic significance of SYT8 in patients with colorectal cancer who received curative surgery

To clarify the clinicopathological and predictive significance of SYT8 expression in patients with colorectal cancer (CRC) who underwent radical tumor resection. The demographic, clinicopathologic, survival outcomes, and SYT8 expression information in CRC patients were extracted from The Cancer Gene Atlas (TCGA) databases. Then we assessed the diagnostic value of SYT8 and determined the underlying prognostic factors of PFI and OS. The SYT8 core genes were identified online based on the Kaplan-Meier Plotter database, and prognostic information was obtained for online analysis. To validate the above results, we retrospectively analyzed 153 CRC patients, and collected their clinicopathological, demographic, and survival information. The clinicopathological features and prognostic value of SYT8 were analysed in patients with colorectal cancer. In total, 643 CRC patients were included from the TCGA database. SYT8 was significantly overexpressed in CRC tissues compared to adjacent tissues (0.84 ± 0.79 vs 0.28 ± 0.30, <italic>p</italic> &lt; 0.01). ROC curve results indicated that SYT8 performed a satisfactory diagnostic value in CRC (AUC: 0.863). Additionally, SYT8 was an independent prognostic factor affecting patients' OS (<italic>p</italic> = 0.01) instead of PFI. The results of retrospective validation demonstrated that SYT8 expression is one of the independent prognostic factors to OS (<italic>p</italic> &lt; 0.05). Moreover, SYT8 expression was positively correlated with lymph node metastasis. SYT8 overexpressed in CRC tissues and could be applied as a diagnostic and prognostic biomarker in these patients after curative surgery.