SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models
These results support SAAP-148 as a candidate for pre-infection prophylaxis and synergistic antibiotic therapy with halicin in skin, broadening the potential of both agents to address AMR bacterial infection.
Authors
- Pieter S. Hiemstra (ORCID: https://orcid.org/0000-0002-0238-5982)
- Patrick R. Lennard (ORCID: https://orcid.org/0000-0002-8390-0463)
- Peter H. Nibbering (ORCID: https://orcid.org/0000-0002-0432-8340)
- Julia R. Dorin (ORCID: https://orcid.org/0000-0002-4363-2310)
Institutions
- Leiden University Medical Center (NL)
- Institute of Immunology (HR)
- Centre for Inflammation Research (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1093/jacamr/dlaf050
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Edinburgh
- Leids Universitair Medisch Centrum