Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma
This study reveals the multifaceted regulatory roles of ubiquitination in HCC. Ubiquitination not only supports proliferation and anti-apoptotic functions within tumor cells but also promotes tumor progression by modulating the activity of immune and stromal cells. Among all ubiquitination-related genes, UBE2C emerges as a potential prognostic biomarker and therapeutic target in HCC, offering new directions for precision treatment of HCC in the future.
Authors
- Zheng Gang Zhou (ORCID: https://orcid.org/0000-0002-7485-1030)
- Yuan Chen (ORCID: https://orcid.org/0000-0001-8799-7664)
- Haikun Yang (ORCID: https://orcid.org/0000-0001-7182-5200)
- Yanjing Wang (ORCID: https://orcid.org/0000-0001-6826-1635)
- Yang Li (ORCID: https://orcid.org/0000-0002-4308-5118)
- Peng Li (ORCID: https://orcid.org/0000-0001-7984-2486)
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fphar.2025.1545472
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61