A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report

Whilst uncommon in pregnancy, hypercalcaemia can lead to significant maternal and fetal morbidity. An important complication of hypercalcaemia is uncontrolled hypertension. This case outlines an example of refractory hypercalcaemia exacerbating an emerging hypertensive crisis. The proposed aetiology was parathyroid hormone-related protein (PTHrP)-mediated hypercalcaemia secondary to a necrotic uterine fibroid. We highlight how effective and prompt involvement of the Maternal Medicine Network and multidisciplinary team led to a successful pregnancy outcome.

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Publication Details

Journal
Obstetric Medicine
Published
2025-04-11
DOI
https://doi.org/10.1177/1753495x251326130
Citations
1
Primary Topic
Bone health and treatments
Type
article
Field-Weighted Citation Impact
1.05
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article

A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report

Carol Postlethwaite, Karan Sampat, Catherine Nelson-Piercy, Chloe Gilkinson et al.
1 citations
Obstetric Medicine
Bone health and treatments
1.05
article

A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report

Carol Postlethwaite, Karan Sampat, Catherine Nelson-Piercy, Chloe Gilkinson, Hannah Beresford
article en
1 citations

Abstract

Whilst uncommon in pregnancy, hypercalcaemia can lead to significant maternal and fetal morbidity. An important complication of hypercalcaemia is uncontrolled hypertension. This case outlines an example of refractory hypercalcaemia exacerbating an emerging hypertensive crisis. The proposed aetiology was parathyroid hormone-related protein (PTHrP)-mediated hypercalcaemia secondary to a necrotic uterine fibroid. We highlight how effective and prompt involvement of the Maternal Medicine Network and multidisciplinary team led to a successful pregnancy outcome.

Obstetric Medicine
King's College London (GB), South London and Maudsley NHS Foundation Trust (GB), Darent Valley Hospital (GB), Medway Maritime Hospital (GB), Kings Health Partners (GB), King's College Hospital (GB), Surrey and Sussex Healthcare NHS Trust (GB)
Good health and well-being
Openalex Percentile: Top 23%
Bone health and treatments
1.05
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A rare example of humoral-related hypercalcaemia in pregnancy secondary to a uterine fibroid: a case report — Carol Postlethwaite, Karan Sampat, et al. · Obstetric Medicine (2025) | TGRS Research Map | TGRS