Rehabilitation improves the effectiveness of nusinersen in children with type 2 spinal muscular atrophy: pNF-H and muscle MRI as potential biomarkers
This study suggests that rehabilitation therapy improves the effectiveness of nusinersen on type-2 SMA patients, and the levels of pNF-H and skeletal muscle MRI can serve as potential biomarkers for evaluating the effectiveness of SMA treatment.
Authors
- Min Zhu (ORCID: https://orcid.org/0000-0002-0706-6390)
- Yifan Sun (ORCID: https://orcid.org/0000-0003-3532-6521)
- Wei Li (ORCID: https://orcid.org/0000-0003-2164-9266)
- Tong Cao (ORCID: https://orcid.org/0000-0002-7994-9627)
- Xiucheng Gao (ORCID: https://orcid.org/0000-0002-5122-8908)
- Xiaoke Zhao
- Dalin Fu
- Yang Li (ORCID: https://orcid.org/0000-0003-1784-6638)
- Xin Cui (ORCID: https://orcid.org/0000-0001-7560-6910)
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fneur.2025.1549587
- Citations
- 2
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 3.25