Neutrophil Extracellular Traps–Associated <scp>RNA</scp> Impedes <scp>CD4</scp><sup>+</sup> Treg Differentiation by <scp>TLR7</scp>–<scp>IRF7</scp> Axis in Ankylosing Spondylitis
Elevated NETs impeded CD4<sup>+</sup> Treg differentiation by activating the TLR7-IRF-7 axis via their associated RNA in AS, and targeting NETs may be a novel treatment strategy for AS and related inflammatory disorders.
Authors
- Yi Zhou (ORCID: https://orcid.org/0000-0002-7962-3977)
- Jiajie Lin (ORCID: https://orcid.org/0000-0003-3338-6264)
- Zhichao Xiao
- Zepeng Su (ORCID: https://orcid.org/0000-0001-7691-7075)
- Jinteng Li
- Zhikun Li (ORCID: https://orcid.org/0000-0002-1732-5931)
- Yanfeng Wu (ORCID: https://orcid.org/0000-0003-3929-9823)
- Zheng Guan (ORCID: https://orcid.org/0000-0001-8617-8114)
- Zhongyu Xie (ORCID: https://orcid.org/0000-0003-2665-6115)
- Wenhui Yu (ORCID: https://orcid.org/0000-0002-0684-5237)
- Yipeng Zeng
Institutions
- Sun Yat-sen University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1002/art.43166
- Citations
- 7
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.58