Sex disparities in alcohol-associated liver disease and subtype differences in alcohol-attributable cancers in the United States
The burden of ALD is substantial and continues to rise in the US, with a particularly notable increase among females. Mortality from alcohol-attributable cancers is also increasing, mainly driven by primary liver cancer and pharyngeal cancer. However, system-wise, gastrointestinal cancer had the highest death attributable to alcohol. These findings highlight the urgent need for public health strategies to tackle ALD, primary liver cancer, and alcoholattributable extrahepatic malignancies.
Authors
- Karn Wijarnpreecha (ORCID: https://orcid.org/0000-0002-6232-6343)
- Kwanjit Duangsonk (ORCID: https://orcid.org/0000-0002-3325-1688)
- Daniel Q. Huang (ORCID: https://orcid.org/0000-0002-5165-5061)
- Luis Antonio Díaz (ORCID: https://orcid.org/0000-0002-8540-4930)
- Amit G. Singal (ORCID: https://orcid.org/0000-0002-1172-3971)
- Soo Young Hwang (ORCID: https://orcid.org/0000-0001-9845-7073)
- Mazen Noureddin (ORCID: https://orcid.org/0000-0003-2127-2040)
- Won-Mook Choi
- Mark Dhinesh Muthiah (ORCID: https://orcid.org/0000-0002-9724-4743)
- Suthat Liangpunsakul
- Pojsakorn Danpanichkul (ORCID: https://orcid.org/0000-0002-9121-165X)
- Primrose Tothanarungroj
- Donghee Kim (ORCID: https://orcid.org/0000-0003-1919-6800)
- Juan Pablo Arab
- Yanfang Pang
- Pimtawan Jatupornpakdee
- Tanuj Mahendru
Institutions
- Ulsan College (KR)
- Texas Tech University (US)
- Cedars-Sinai Medical Center (US)
- Houston Methodist (US)
- University of Arizona (US)
- Pontificia Universidad Católica de Chile (CL)
- University of Phoenix (US)
- Virginia Commonwealth University (US)
- Asan Medical Center (KR)
- Banner Health (US)
- University of California San Diego (US)
- University of Ulsan (KR)
- Banner - University Medical Center Phoenix (US)
- Methodist Hospital (US)
- Richard L. Roudebush VA Medical Center (US)
- Guangxi University of Chinese Medicine (CN)
- Banner - University Medical Center Tucson (US)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- National University Health System (SG)
- Indiana University School of Medicine
- Chiang Mai University (TH)
- Indiana University – Purdue University Indianapolis (US)
- Indiana University (US)
- The University of Texas Southwestern Medical Center (US)
- Texas Tech University Health Sciences Center (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3350/cmh.2025.0169
- Citations
- 9
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 12.19
Funders
- National Research Foundation
- National Research Foundation Singapore
- Astellas Pharma
- Medical Research Council
- National Medical Research Council