Impact of Long‐Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using <sup>31</sup> P/ <sup>1</sup> H MRS and MRI
Long-term fasting did not alter muscle metabolism or performance, nor induced structural or inflammatory changes. The decrease in muscle volume is minor when accounting for glycogen and water depletion during fasting. Fat is relocated to the intracellular compartment of myocytes. Both anaerobic and aerobic metabolic pathways remain unchanged after 12 days of fasting in both sexes and older subjects. This suggests that human muscles, like those in animals, have evolved to withstand seasonal food shortages and endure long fasting periods.
Authors
- Magalie Viallon (ORCID: https://orcid.org/0000-0001-9118-0438)
- Antoine Naëgel (ORCID: https://orcid.org/0000-0002-5354-6475)
- Djahid Kennouche (ORCID: https://orcid.org/0000-0002-3914-2669)
- Thomas Grenier (ORCID: https://orcid.org/0000-0002-3630-5856)
- Robin Mesnage (ORCID: https://orcid.org/0000-0003-1732-4741)
- H. Ratiney (ORCID: https://orcid.org/0000-0002-0662-2172)
- Franziska Grundler (ORCID: https://orcid.org/0000-0002-4352-3990)
- Pierre Croisille (ORCID: https://orcid.org/0000-0003-4019-3460)
- Robin Schultze
- Benjamin Leporq (ORCID: https://orcid.org/0000-0002-3408-4156)
- Françoise Wilhelmi de Toledo (ORCID: https://orcid.org/0000-0002-4578-5812)
- Thu Thuy Nguyen (ORCID: https://orcid.org/0000-0001-7430-6828)
- J.-B. Guy
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- King's College London (GB)
- Institute Cancer De La Loire Lucien Neuwirth (FR)
- Buchinger Wilhelmi (DE)
- Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (FR)
- Siemens (France) (FR)
- Laboratoire Interuniversitaire de Biologie de la Motricité (FR)
- Werner-Wicker-Klinik (DE)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Université Savoie Mont Blanc (FR)
- Université Jean Monnet (FR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/jcsm.13773
- Citations
- 3
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Agence Nationale de la Recherche
- LabEx PRIMES