MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation
Our results revealed that TRIB3 and COP1 act as key mediators in MET-driven HCC progression. Targeting the MET-TRIB3-FOXO1 regulatory axis may offer a promising therapeutic strategy to counteract oncogenic signaling and impede HCC advancement.
Authors
- Jie Jin (ORCID: https://orcid.org/0000-0002-8166-9915)
- Yiming Luo (ORCID: https://orcid.org/0000-0002-6028-2746)
- Dean Rao (ORCID: https://orcid.org/0000-0002-1134-6934)
- Junli Lu (ORCID: https://orcid.org/0009-0002-9268-9003)
- Limin Xia (ORCID: https://orcid.org/0000-0002-6327-6034)
- Ziyong Sun (ORCID: https://orcid.org/0000-0002-6443-9755)
- Wenjie Huang (ORCID: https://orcid.org/0000-0001-9726-4798)
- Tiantian Wang (ORCID: https://orcid.org/0009-0003-9260-3254)
- Han Li (ORCID: https://orcid.org/0000-0003-4978-6502)
- Huifang Liang (ORCID: https://orcid.org/0000-0001-6874-3634)
- Chenan Fu
- Feimu Fan
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3350/cmh.2024.1163
- Citations
- 9
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Natural Science Foundation of Hubei Province