Antimicrobial Piano‐Stool and Polypyridyl Ru(II) Complexes with Thiazolhidrazinylidene‐Chroman‐2,4‐Dione: Tautomerism, Membrane Disruption, and Electron Transport Interference
A library of (η<sup>6</sup>-p-cymene)Ru(II) and Ru(II) bis-bpy complexes bearing thiazolhidrazinylidene-chroman-2,4-dione was synthesized, characterized, and the molecules are evaluated for their antibacterial activity and cytotoxicity. From this library, several compounds are identified as being active against Methicillin-resistant Staphylococcus aureus and Methicillin-sensitive S. aureus. A polypyridyl complex showed a noteworthy minimum inhibitor concentration of 3.1 μm and no toxicity in healthy eukaryotic cells with a therapeutic index of >32. Active complexes appear to exert their antibiotic activity by affecting both the permeabilization of the bacterial membrane and/or the electron transport chain.
Authors
- Aurélien Crochet (ORCID: https://orcid.org/0000-0002-4763-2764)
- Fatlinda Rahmani (ORCID: https://orcid.org/0009-0003-0296-8410)
- Youri Cortat (ORCID: https://orcid.org/0009-0001-9414-2098)
- Fabio Zobi (ORCID: https://orcid.org/0000-0002-9077-7184)
Institutions
- University of Fribourg (CH)
Publication Details
- Journal
- ChemBioChem
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1002/cbic.202401025
- Citations
- 2
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 2.09