A conjugated molecule based on tetra-fused thienoisoindigo ribbon for NIR-II photothermal cancer therapy
Water-soluble nanoparticles (NPs) based on the well-defined 4ThIID molecules, namely 4ThIID NPs, were prepared. Benefiting from the strong NIR-II absorption and high photothermal conversion properties of 4ThIID, the <i>ε</i><sub>1064</sub> × PTCE<sub>1064</sub> value of 4ThIID NPs reaches 9.18 × 10<sup>4</sup>, which is the highest value among the reported NIR-II photothermal small molecules. <i>In vivo</i> experiments show that 4ThIID NPs can effectively inhibit the growth of tumors in mouse models under the irradiation of a 1064 nm laser.
Authors
- Jiayi Chen
- Yang Zong (ORCID: https://orcid.org/0000-0002-3776-7382)
- Yue Gao (ORCID: https://orcid.org/0009-0001-5757-2873)
- Yu Jiang
- Hong Chen (ORCID: https://orcid.org/0000-0001-7799-4961)
- Xiaohua Zheng (ORCID: https://orcid.org/0000-0002-8045-279X)
- Junjie Wu
- Yangwei Zhu
Institutions
- Nantong University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01712b
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61