The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD <sup>+</sup> Therapy in HFpEF
The canonical ketogenic enzyme, HMGCS2, mediates the therapeutic effects of the oxidized form of nicotinamide adenine dinucleotide repletion in HFpEF by restoring normal lipid metabolism and mitochondrial function.
Authors
- John O’Sullivan (ORCID: https://orcid.org/0000-0001-8016-5128)
- Yen Chin Koay (ORCID: https://orcid.org/0000-0002-6704-5495)
- Bailey McIntosh
- David M. Kaye (ORCID: https://orcid.org/0000-0003-4058-0372)
- Benjamin Hunter (ORCID: https://orcid.org/0000-0001-6100-9760)
- Mark Larance (ORCID: https://orcid.org/0000-0002-8579-2267)
- Yang Cao (ORCID: https://orcid.org/0000-0002-0058-614X)
- Yan‐Chuang Han (ORCID: https://orcid.org/0009-0000-9841-8189)
- Aldons Jake Lusis (ORCID: https://orcid.org/0000-0001-9013-0228)
- Yu Bai (ORCID: https://orcid.org/0000-0003-1117-3735)
- Sean Lal (ORCID: https://orcid.org/0000-0002-5841-560X)
- Paul G. Bannon (ORCID: https://orcid.org/0000-0002-3117-7250)
- Yann Huey Ng (ORCID: https://orcid.org/0000-0002-3913-6429)
- Christopher M. Loughrey (ORCID: https://orcid.org/0000-0003-1297-9159)
- Xiaosuo Wang (ORCID: https://orcid.org/0000-0003-3487-4614)
- Ashish Misra (ORCID: https://orcid.org/0000-0002-8901-4788)
- Saki Tomita (ORCID: https://orcid.org/0000-0002-0107-0778)
Institutions
- University of Science and Technology of China (CN)
- The University of Sydney (AU)
- Baker Heart and Diabetes Institute (AU)
- University of California, Los Angeles (US)
- Royal Prince Alfred Hospital (AU)
- The Heart Research Institute (AU)
- The Alfred Hospital (AU)
- UNSW Sydney (AU)
- Baird Institute (AU)
- Monash University (AU)
- Technische Universität Dresden (DE)
- University of Glasgow (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1161/circresaha.124.325550
- Citations
- 12
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 13.97