The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD <sup>+</sup> Therapy in HFpEF

The canonical ketogenic enzyme, HMGCS2, mediates the therapeutic effects of the oxidized form of nicotinamide adenine dinucleotide repletion in HFpEF by restoring normal lipid metabolism and mitochondrial function.

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Publication Details

Journal
Circulation Research
Published
2025-04-11
DOI
https://doi.org/10.1161/circresaha.124.325550
Citations
12
Primary Topic
Diet and metabolism studies
Type
article
Field-Weighted Citation Impact
13.97
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article

The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD + Therapy in HFpEF

John O’Sullivan, Yen Chin Koay, Bailey McIntosh, David M. Kaye et al.
12 citations
Circulation Research
Diet and metabolism studies
13.97
article

The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD + Therapy in HFpEF

John O’Sullivan, Yen Chin Koay, Bailey McIntosh, David M. Kaye, Benjamin Hunter, Mark Larance, Yang Cao, Yan‐Chuang Han, Aldons Jake Lusis, Yu Bai, Sean Lal, Paul G. Bannon, Yann Huey Ng, Christopher M. Loughrey, Xiaosuo Wang, Ashish Misra, Saki Tomita
article en
12 citations

Abstract

The canonical ketogenic enzyme, HMGCS2, mediates the therapeutic effects of the oxidized form of nicotinamide adenine dinucleotide repletion in HFpEF by restoring normal lipid metabolism and mitochondrial function.

Circulation ResearchVol. 136(10)
University of Science and Technology of China (CN), The University of Sydney (AU), Baker Heart and Diabetes Institute (AU), University of California, Los Angeles (US), Royal Prince Alfred Hospital (AU), The Heart Research Institute (AU), The Alfred Hospital (AU), UNSW Sydney (AU), Baird Institute (AU), Monash University (AU), Technische Universität Dresden (DE), University of Glasgow (GB)
Good health and well-being
Openalex Percentile: Top 1%
Diet and metabolism studies
13.97
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