Unveiling the potential biochemical effects of selected heterocyclic compounds as human Type-A γ-aminobutyric acid (GABA A) Modulator: An Insilico Approach
Our findings from this work may open door for the design of several 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-(benzyloxy)-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile derivatives as potential Type-A γ-aminobutyric acid inhibitors.
Authors
- Ehimen Annastasia Erazua (ORCID: https://orcid.org/0000-0001-6887-6381)
- Adesoji Alani Olanrewaju (ORCID: https://orcid.org/0000-0001-6084-4465)
- Sunday Adewale Akintelu (ORCID: https://orcid.org/0000-0001-8919-3029)
- Oluwakemi Ebenezer (ORCID: https://orcid.org/0000-0003-1054-9665)
- Abel Kolawole Oyebamiji (ORCID: https://orcid.org/0000-0002-8932-6327)
- David O. Adekunle (ORCID: https://orcid.org/0000-0001-9458-8834)
- Omowumi Temitayo Akinola (ORCID: https://orcid.org/0000-0003-2155-4697)
- Samson Olusegun Afolabi (ORCID: https://orcid.org/0000-0002-6174-5044)
- Faith Eniola Olujinmi
- Ayodeji Arnold Olaseinde
Institutions
- University of Alberta (CA)
- ITMO University (RU)
- University of Ibadan (NG)
- Bowen University (NG)
- Clemson University (US)
Publication Details
- Journal
- Biotechnology Reports
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.btre.2025.e00894
- Primary Topic
- GABA and Rice Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00