Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2–Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy
Our study reveals novel mechanisms of ARVC caused by <i>DSC2</i> loss of function, supported by human and mouse data. Loss of <i>Myl7</i> contributes to reduced cardiac contractility in ARVC and dilated cardiomyopathy with right ventricular systolic dysfunction. Dsc2 mRNA treatment demonstrated significant therapeutic potential in ARVC and transverse aortic constriction models, providing a basis for future clinical applications.
Authors
- Jun Li (ORCID: https://orcid.org/0000-0002-4096-0159)
- Jennifer Ming Jen Wong (ORCID: https://orcid.org/0009-0000-7181-1642)
- Feng Huang (ORCID: https://orcid.org/0000-0003-1459-5394)
- Jianguo Jia (ORCID: https://orcid.org/0000-0002-6993-6080)
- Chenxing Huang
- Kejia Jin (ORCID: https://orcid.org/0000-0002-0472-3906)
- Wendi Yan (ORCID: https://orcid.org/0000-0001-8173-5073)
- Jinzhong Lin (ORCID: https://orcid.org/0000-0001-5666-8526)
- Yi Jin (ORCID: https://orcid.org/0000-0001-9704-973X)
- Junyu Zhai (ORCID: https://orcid.org/0000-0003-3129-8084)
- Huanjie Yang (ORCID: https://orcid.org/0000-0002-2424-4937)
- Yamei Xu (ORCID: https://orcid.org/0000-0001-9969-613X)
- Yang Zhang (ORCID: https://orcid.org/0000-0003-0456-2775)
- Xialian Xu (ORCID: https://orcid.org/0000-0001-7523-5718)
- Yan Zou (ORCID: https://orcid.org/0000-0001-9740-317X)
- Hui Gong (ORCID: https://orcid.org/0000-0002-6718-9341)
- Qifu Li (ORCID: https://orcid.org/0000-0001-7249-6445)
- Jing Lü (ORCID: https://orcid.org/0000-0002-3418-8561)
- Juan Shen (ORCID: https://orcid.org/0000-0001-8448-9242)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-2549-0398)
- Zhipeng Lian (ORCID: https://orcid.org/0009-0002-6608-6276)
- Xin-yue Ren (ORCID: https://orcid.org/0009-0009-4482-6481)
- Hang Yu
- Yuxiang Dai (ORCID: https://orcid.org/0000-0003-2479-8996)
Institutions
- BGI Group (China) (CN)
- Shanghai Medical College of Fudan University (CN)
- University of Shanghai for Science and Technology (CN)
- Fudan University (CN)
- Karolinska Institutet (SE)
- First Affiliated Hospital of GuangXi Medical University (CN)
- National Clinical Research (US)
- Zhongshan Hospital (CN)
- San Diego Cardiac Center (US)
- Wuhan YZY Biopharma (China) (CN)
- State Key Laboratory of Genetic Engineering
- Jisc (GB)
Publication Details
- Journal
- Circulation
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1161/circulationaha.124.072340
- Citations
- 7
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 9.72