The function of conducting a direct replication may be different than typically assumed: understanding contextuality and asymmetry

Direct replication, that is, analysis of new data with the same study protocol, has a purpose in checking the reliability of earlier research findings. However, using a case study we show that direct replication can have an additional function. We find that identical numerical replication results can be the result of differential effects of biases across different data sources and we draw attention to the risk of asymmetric evaluation in such cases. We then show how exact replications have the important function to bring into focus the contextualities inherent in the generation of research findings. Understanding the contextuality allows for a better and richer understanding of what the results imply.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Epidemiology
Published
2025-04-11
DOI
https://doi.org/10.1016/j.jclinepi.2025.111785
Citations
1
Primary Topic
Cancer Genomics and Diagnostics
Type
article
Field-Weighted Citation Impact
0.94

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The function of conducting a direct replication may be different than typically assumed: understanding contextuality and asymmetry

Rolf H. H. Groenwold, Kim Luijken, Patricia Bruijning‐Verhagen, Annemarijn R de Boer et al.
1 citations
Journal of Clinical Epidemiology
Cancer Genomics and Diagnostics
0.94
article

The function of conducting a direct replication may be different than typically assumed: understanding contextuality and asymmetry

Rolf H. H. Groenwold, Kim Luijken, Patricia Bruijning‐Verhagen, Annemarijn R de Boer, Stephanie Meirmans
article en
1 citations

Abstract

Direct replication, that is, analysis of new data with the same study protocol, has a purpose in checking the reliability of earlier research findings. However, using a case study we show that direct replication can have an additional function. We find that identical numerical replication results can be the result of differential effects of biases across different data sources and we draw attention to the risk of asymmetric evaluation in such cases. We then show how exact replications have the important function to bring into focus the contextualities inherent in the generation of research findings. Understanding the contextuality allows for a better and richer understanding of what the results imply.

Journal of Clinical EpidemiologyVol. 183
Heidelberg University (DE), Leiden University Medical Center (NL), University Hospital Heidelberg (DE), University Medical Center Utrecht (NL), Amsterdam Neuroscience (NL), Amsterdam University Medical Centers (NL), University of Amsterdam (NL)
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Openalex Percentile: Top 26%
Cancer Genomics and Diagnostics
0.94
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

The function of conducting a direct replication may be different than typically assumed: understanding contextuality and asymmetry — Rolf H. H. Groenwold, Kim Luijken, et al. · Journal of Clinical Epidemiology (2025) | TGRS Research Map | TGRS