Endothelial SMAD4 Deficiency Promotes Pulmonary Hypertension by Impairing Cell Adhesion and Extracellular Matrix Organization
SMAD4 deficiency in endothelial cells, but not smooth muscle cells, plays a pathogenic role in pulmonary hypertension, via dampening endothelial cell-cell and cell-matrix adhesions and ECM organization.
Authors
- Xuetong Zhou (ORCID: https://orcid.org/0000-0003-1685-0301)
- Keli Liu (ORCID: https://orcid.org/0000-0001-8008-2162)
- Yong Dai (ORCID: https://orcid.org/0000-0002-6840-9158)
- Wenyu Lv (ORCID: https://orcid.org/0009-0002-2523-448X)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
- Jingfeng Wang (ORCID: https://orcid.org/0000-0002-5827-7876)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-6103-1498)
- Xun Chen (ORCID: https://orcid.org/0000-0001-7961-7908)
- Yunhua Li (ORCID: https://orcid.org/0000-0002-0676-7689)
- Yangxin Chen (ORCID: https://orcid.org/0000-0003-2051-9320)
- Lei Zeng (ORCID: https://orcid.org/0000-0003-1397-8852)
- Jiaqi He (ORCID: https://orcid.org/0000-0003-3985-5738)
- Xinyu Gu (ORCID: https://orcid.org/0009-0002-7539-8335)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1161/hypertensionaha.124.22782
- Citations
- 6
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.11