Trimester-specific associations of exposure to epoxide alkanes, alkenals, and 1,3-butadiene with preschool children’s intellectual development: A birth cohort study in Wuhan, China

The impact of prenatal exposure to contaminants with neurotoxicity like epoxide alkanes (ethylene oxide, propylene oxide), alkenals (acrolein, crotonaldehyde), and 1,3-butadiene on children's intellectual development remains underreported, and related sensitive window is of interest. In this cohort study, metabolites of these contaminants were measured in 3,081 urine samples from 1,027 pregnant women across three trimesters. Children's intelligence quotient was evaluated at 4-6 years old. Generalized estimating equation models showed that higher urinary concentrations of 2-hydroxypropyl mercapturic acid (a metabolite of propylene oxide), 3-hydroxypropyl mercapturic acid (HPMMA, a metabolite of crotonaldehyde), and the sum of acrolein metabolites in the first trimester were associated with lower visual spatial index (VSI), working memory index (WMI), or processing speed index scores. Quantile g-computation models revealed that co-exposure to these contaminants in the first trimester were associated with lower VSI (β = -0.98, 95 % CI: -1.94, -0.03) and WMI (β = -0.86, 95 % CI: -1.66, -0.06) scores, with HPMMA as the major contributor. These results suggested that early pregnancy could be a sensitive window during which exposure to propylene oxide, crotonaldehyde, and acrolein may impair offspring's intellectual development.