Research Progress on Serological Markers of Primary Sjögren’s Syndrome

原发性干燥综合征(pSS)是一种独特的系统性的自身免疫性疾病，涉及唾液和泪腺以及多个其他器官系统的损伤，其与多种血清学标志物具有相关性，如抗SSA抗体、抗SSB抗体、抗Ro52抗体、抗着丝点抗体、抗M3R抗体、水通道蛋白5、抗唾液腺蛋白1抗体等。本文将对近年来血清学标志物在pSS疾病的发病机制、临床表现以及预后等方面的作用进行综述，旨在为临床实践和科学研究提供新的思路与研究方向。Primary Sjögren’s syndrome (pSS) is a unique systemic autoimmune disease involving damage to salivary and lacrimal glands, as well as multiple other organ systems, that is associated with multiple serological markers, such as anti-SSA antibodies, anti-SSB antibodies, anti-RO52 antibodies, anti-centromere antibodies, anti-M3R antibodies, aquaporin 5, anti-salivary gland protein 1 antibodies and so on. This article will review the recent serological markers in the pathogenesis, clinical manifestations and prognosis of pSS, aiming to provide new ideas and research directions for clinical practice and scientific research.