Acupuncture regulates astrocyte neurotoxic polarization to protect blood–brain barrier integrity in delayed thrombolysis through mediating ERK1/2/Cx43 axis
Acupuncture mitigates delayed thrombolysis-induced brain injury by modulating astrocyte polarization via the ERK1/2-Cx43 pathway. These findings highlight acupuncture as a potential strategy to enhance thrombolytic therapy safety in ischemic stroke.
Authors
- Wentao Xu (ORCID: https://orcid.org/0000-0003-3490-2769)
- Yu Gu (ORCID: https://orcid.org/0000-0003-1793-7409)
- Guang-Xia Ni (ORCID: https://orcid.org/0000-0002-6775-5075)
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-1980-0468)
- Zhihui Zhang (ORCID: https://orcid.org/0000-0003-2624-9923)
- Xin-Chang Zhang
- Zheng Huang (ORCID: https://orcid.org/0000-0001-5590-3328)
Institutions
- Nanjing University of Chinese Medicine (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.ibneur.2025.04.005
- Citations
- 5
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.91
Funders
- National Natural Science Foundation of China