Investigating the antimicrobial activity of 1-heteroaryl benzotriazole silver compounds
Five (1-5) Ag(i) compounds, derived from different <i>N</i>,<i>N</i>'-bidentate 1-heteroaryl benzotriazole ligands, were synthesised and characterised using SXRD, IR, UV-Vis, elemental analysis, ESI-MS, and NMR. Variations in ligands and counter-anions produced distinct structures and morphologies. Preliminary antimicrobial testing at the micromolar level, in DMSO, revealed that only compound 2, based on 1-(2-pyridyl)benzotriazole and triflate anion, exhibited interesting antimicrobial properties, thus marking the introduction of a new class of Ag(i) compounds in medicinal inorganic chemistry.
Authors
- S.K. Hadjikakou (ORCID: https://orcid.org/0000-0001-9556-6266)
- Simon John Coles (ORCID: https://orcid.org/0000-0001-8414-9272)
- George E. Κostakis (ORCID: https://orcid.org/0000-0002-4316-4369)
- C.N. Banti (ORCID: https://orcid.org/0000-0001-6727-2711)
- Ghadah Abdullah S. Al Jomeh
- Graham J. Tizzard (ORCID: https://orcid.org/0000-0003-1901-0607)
- Ahmed Elzein
Institutions
- University of Sussex (GB)
- University of Ioannina (GR)
- University of Southampton (GB)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra01072a
- Citations
- 3
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- University of Southampton
- Imam Mohammed Ibn Saud Islamic University
- Engineering and Physical Sciences Research Council