Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response

This study identifies IL-6 as a key mediator of tubule-fibroblast crosstalk in an acidic milieu, promoting inflammatory processes. Acidosis induces IL-6 expression, secretion, and biological effects, with p38 kinase as a crucial mediator. If validated in vivo, these findings could enhance understanding of CKD and support early interventions.

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Publication Details

Journal
Cell Communication and Signaling
Published
2025-04-11
DOI
https://doi.org/10.1186/s12964-025-02180-5
Citations
1
Primary Topic
Eicosanoids and Hypertension Pharmacology
Type
article
Field-Weighted Citation Impact
1.11
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article

Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response

Michael Kopf, Michael Gekle, Marie-Christin Schulz, Nathalie Wolff
1 citations
Cell Communication and Signaling
Eicosanoids and Hypertension Pharmacology
1.11
article

Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response

Michael Kopf, Michael Gekle, Marie-Christin Schulz, Nathalie Wolff
article en
1 citations

Abstract

This study identifies IL-6 as a key mediator of tubule-fibroblast crosstalk in an acidic milieu, promoting inflammatory processes. Acidosis induces IL-6 expression, secretion, and biological effects, with p38 kinase as a crucial mediator. If validated in vivo, these findings could enhance understanding of CKD and support early interventions.

Cell Communication and SignalingVol. 23(1)
Martin Luther University Halle-Wittenberg (DE)
Good health and well-being
Openalex Percentile: Top 24%
Eicosanoids and Hypertension Pharmacology
1.11
DOIOpen Access PDFOpenAlex
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Acidosis-induced p38-kinase activation triggers an IL-6-mediated crosstalk of renal proximal tubule cells with fibroblasts leading to their inflammatory response — Michael Kopf, Michael Gekle, et al. · Cell Communication and Signaling (2025) | TGRS Research Map | TGRS