<scp>APOBEC3B</scp> Does Not Promote Tumor Progression in <i>Tp53</i> Hemizygous Mice
We developed a Cre inducible A3B transgenic mouse model bearing single copy of A3B gene. Although the introduction of A3B overexpression did not accelerate tumor development in Tp53 hemizygous mice, our mouse model with A3B overexpression is well-validated and useful for further research.
Authors
- Ryosuke Nomura (ORCID: https://orcid.org/0000-0002-9442-5522)
- Akifumi Takaori‐Kondo (ORCID: https://orcid.org/0000-0001-7678-4284)
- Hiroyuki Yamazaki (ORCID: https://orcid.org/0000-0002-7690-5522)
- Yugo Kawai
- Yoshihito Horisawa
- Hiroyuki Matsui (ORCID: https://orcid.org/0000-0003-1956-9603)
- Yoshinobu Konishi (ORCID: https://orcid.org/0000-0003-1212-7212)
- June Takeda (ORCID: https://orcid.org/0000-0003-0729-2344)
- Tadahiko Matsumoto (ORCID: https://orcid.org/0000-0002-2362-4612)
- Kotaro Shirakawa (ORCID: https://orcid.org/0000-0002-7469-1276)
- Yasuhiro Kazuma (ORCID: https://orcid.org/0000-0002-1046-8286)
- Yusuke Tashiro
- Suguru Takeuchi (ORCID: https://orcid.org/0000-0002-6543-1835)
Institutions
- Kyoto University (JP)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/cnr2.70189
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japanese Society of Hematology
- Japan Society for the Promotion of Science