Transferrin and Borneol-Enhanced Liposomes for Targeted Rapamycin Delivery in TBI
Our study highlights TF-RAPA/BO-LIP as a promising strategy for delivering RAPA across the BBB, substantially enhancing its therapeutic efficacy for TBI. This novel liposomal system not only improves RAPA bioavailability but also offers significant neuroprotection, potentially transforming the clinical management of TBI.
Authors
- Zhongwen Yuan (ORCID: https://orcid.org/0000-0002-5082-7909)
- Zhengrong Mei
- J. C. K. Lai (ORCID: https://orcid.org/0000-0001-5841-1134)
- Pengke Yan (ORCID: https://orcid.org/0000-0002-8356-2986)
- Shihong Cai
- Yanfang Chen (ORCID: https://orcid.org/0000-0003-4153-4669)
- Mingjie Gong
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s489165
- Citations
- 4
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Guangzhou Medical University
- Guangzhou Municipal Science and Technology Project