Mechanisms of DEHP in the prostate carcinogenesis: A comprehensive bioinformatics analysis
• Network toxicology revealed 115 targets, like BCL2 and CASP3, in DEHP-linked prostate cancer toxicity. • Enrichment analysis revealed the involvement of these genes in the prominent PI3K-AKT signaling pathway in prostate cancer. • Molecular docking demonstrated binding between DEHP and prostate cancer-related target proteins.
Authors
- Jie Chen (ORCID: https://orcid.org/0000-0001-7472-5539)
- Dehong Cao (ORCID: https://orcid.org/0000-0001-7310-8299)
- Liangren Liu (ORCID: https://orcid.org/0000-0001-7597-6241)
- Biao Ran
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Asian Journal of Surgery
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.asjsur.2025.03.268
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China