Association between mental disorders and trigeminal neuralgia: a cohort study and Mendelian randomization analysis
Longer disease duration and broader trigeminal nerve involvement were independently associated with increased severity of depressive, anxiety, and insomnia symptoms, highlighting the importance of early clinical intervention in patients with TN. And results of MR analysis provide evidence supporting a causal relationship between MDs and TN. In contrast to the traditional view that pain causes mood changes such as anxiety and depression, a variety of MDs such as anxiety, depression, and insomnia also alter the risk of developing TN.
Authors
- Ke Yang (ORCID: https://orcid.org/0000-0003-0028-2717)
- Mingxiao Li (ORCID: https://orcid.org/0000-0002-4150-3080)
- Jianke Wang (ORCID: https://orcid.org/0000-0001-5370-7235)
- Yu Duan (ORCID: https://orcid.org/0000-0003-4316-8586)
- Jiang Liu (ORCID: https://orcid.org/0000-0002-0654-707X)
- Ziyi Zhang (ORCID: https://orcid.org/0009-0005-9492-3192)
- Ze Zhang (ORCID: https://orcid.org/0000-0001-7196-6839)
- Hanlin Liu (ORCID: https://orcid.org/0009-0004-9923-0523)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s10194-025-02026-y
- Citations
- 10
- Primary Topic
- Trigeminal Neuralgia and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 14.72
Funders
- Natural Science Foundation of Beijing Municipality
- China-Japan Friendship Hospital