Poor glymphatic function is associated with mild cognitive impairment and its progression to Alzheimer's disease: A DTI-ALPS study
High ALPS index decreases MCI risk and delays MCI progression to AD by approximately 3.5 years. Aβ in choroid plexus, tau in cortex, and executive function may partially mediate the MCI-AD progression in relation to ALPS index.
Authors
- Xuehuan Liu
- Weili Xu (ORCID: https://orcid.org/0000-0001-6140-2968)
- Wei Ba (ORCID: https://orcid.org/0000-0003-3472-2776)
- Michelle M. Dunk (ORCID: https://orcid.org/0000-0003-1927-2818)
- Cuiping Bao (ORCID: https://orcid.org/0009-0001-0537-4840)
- Xiaojun Lian (ORCID: https://orcid.org/0000-0002-9161-1004)
- Yiming Li (ORCID: https://orcid.org/0000-0001-8376-6244)
- Chong Chen (ORCID: https://orcid.org/0000-0002-8420-1410)
- Jun Liu (ORCID: https://orcid.org/0000-0001-7253-6283)
- Jiao Wang (ORCID: https://orcid.org/0000-0003-2416-191X)
- Jun Yang (ORCID: https://orcid.org/0000-0001-6085-9245)
- Hongbin Luo (ORCID: https://orcid.org/0000-0002-1643-3463)
- Rongrong Yang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Sichuan University (CN)
- Tianjin First Center Hospital (CN)
- Karolinska Institutet (SE)
- West China Hospital of Sichuan University (CN)
- Tianjin Centers for Disease Control and Prevention (CN)
- Tianjin Fourth Central Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100156
- Citations
- 14
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 12.73