<scp>ALKBH5</scp> Inhibits <scp>YTHDF2</scp>‐<scp>m6A</scp>‐Mediated Degradation of <scp>RCN1 mRNA</scp> to Promote Keloid Formation by Activating <scp>IRE1α</scp>‐<scp>XBP1</scp>‐Mediated <scp>ER</scp> Stress
Our data revealed that RCN1 was upregulated by ALKBH5 to promote keloid formation by activating IRE1α-XBP1-mediated ER stress, RCN1 may be a potential biomarker for treatment of keloid.
Authors
- Lu Zhang (ORCID: https://orcid.org/0000-0002-1580-6774)
- Fangfang Bi (ORCID: https://orcid.org/0000-0002-6770-709X)
- Min Shi (ORCID: https://orcid.org/0009-0008-3403-1979)
- Zhuo Zhou (ORCID: https://orcid.org/0009-0001-0978-9699)
Institutions
- Northwest University (CN)
- Xi'an Peihua University (CN)
- Northwest University First Hospital
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/jocd.70177
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Basic Research Program of Shaanxi Province