Zeolitic Imidazolate Framework-90 Treats Fungal Keratitis by Promoting Macrophage Apoptosis and Targeting Increased Mitochondrial Reactive Oxygen Species in Aspergillus Fumigatus
ZIF-90 has therapeutic effects on fungal keratitis, which could break the protective organelles of <i>A. fumigatus</i>, such as the cell wall. In addition, ZIF-90 can also be targeted to increase the amount of mtROS in fungi and promote apoptosis of macrophages. The results demonstrated that both zinc ions and imidazole possessed antimicrobial and anti-inflammatory effects. In addition, ZIF-90 exhibited better antifungal properties than ZIF-8, ZIF-67, and MOF-74 (Zn).
Authors
- Daohao Li (ORCID: https://orcid.org/0000-0003-2040-5227)
- Menghui Chi (ORCID: https://orcid.org/0000-0002-2219-5799)
- Jing Lin (ORCID: https://orcid.org/0000-0001-9865-2098)
- Cui Li (ORCID: https://orcid.org/0000-0002-0585-4916)
- Qian Wang (ORCID: https://orcid.org/0000-0003-3820-9494)
- Ziyi Wang (ORCID: https://orcid.org/0000-0003-4901-3438)
- Xueyun Fu (ORCID: https://orcid.org/0009-0000-6923-687X)
- Guiqiu Zhao
- Lina Zhang (ORCID: https://orcid.org/0009-0005-3255-2285)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s517169
- Citations
- 5
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.54