Tumor cell-derived osteopontin promotes tumor fibrosis indirectly via tumor-associated macrophages
This study shows that tumor-derived OPN primarily drives TAM enrichment in mouse cancer model, indirectly promoting tumor fibrosis through Ly6C<sup>+</sup>CD206<sup>-/low</sup> and Ly6C<sup>-</sup>CD206<sup>high</sup> TAMs. Our findings have potential application in preventing tumors from excessive fibrosis and enhancing the efficacy of immunotherapy and chemotherapy.
Authors
- Wentao Liu (ORCID: https://orcid.org/0000-0001-5534-7173)
- Yong‐Guang Yang (ORCID: https://orcid.org/0000-0003-4985-1247)
- Yuying Tan
- Xiaoying Zhang (ORCID: https://orcid.org/0009-0009-0232-1936)
- Xiaocong Wang (ORCID: https://orcid.org/0000-0003-3690-4311)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-1441-5528)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Jilin International Studies University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s12967-025-06444-z
- Citations
- 3
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Natural Science Foundation of Jilin Province
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Jilin University
- National Key Research and Development Program of China