Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers
Carbamazepine decreased FXaI exposure to a clinically relevant extent and dose adjustment may be required to maintain an adequate anticoagulant effect, whereas gabapentin and pregabalin do not require dose adjustment of FXaI.
Authors
- Alexander Lenard
- David Czock (ORCID: https://orcid.org/0000-0003-1217-5134)
- Walter E. Haefeli (ORCID: https://orcid.org/0000-0003-0672-6876)
- Jürgen Burhenne (ORCID: https://orcid.org/0000-0002-2190-1698)
- Kathrin I. Foerster (ORCID: https://orcid.org/0000-0001-8583-7181)
- Antje Blank (ORCID: https://orcid.org/0000-0001-8743-5194)
- Andreas D. Meid (ORCID: https://orcid.org/0000-0003-3537-3205)
- Felicitas Stoll (ORCID: https://orcid.org/0000-0003-3005-0546)
- Gerd Mikus (ORCID: https://orcid.org/0000-0003-1783-133X)
- Simon Hermann (ORCID: https://orcid.org/0000-0002-5561-8022)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.3389/fphar.2025.1542063
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Universitätsklinikum Heidelberg
- Daiichi Sankyo Europe