Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis
Belumosudil was associated with non-clinically meaningful mRSS improvement. The histologic features that significantly correlated with Fibrosis Score changes (e.g., hyalinized collagen, SC fat loss) were distinct from those associated with mRSS changes (e.g., telangiectasia and perivascular CD3 +). These data suggest that AI applied to SSc biopsies may be useful for quantifying pathologic features of SSc beyond skin thickness.
Authors
- Vijaya B. Kolachalama (ORCID: https://orcid.org/0000-0002-5312-8644)
- F. Perry Wilson (ORCID: https://orcid.org/0000-0002-2633-2412)
- Alyssa Williams (ORCID: https://orcid.org/0000-0002-0130-8707)
- Kathleen Aren (ORCID: https://orcid.org/0000-0003-4770-2643)
- Elizabeth R. Volkmann (ORCID: https://orcid.org/0000-0003-3750-6569)
- Mary Carns (ORCID: https://orcid.org/0000-0002-5063-156X)
- J. Matthew Mahoney (ORCID: https://orcid.org/0000-0003-1425-5939)
- Gauri Panse (ORCID: https://orcid.org/0000-0002-5762-3490)
- Elana J. Bernstein (ORCID: https://orcid.org/0000-0001-5560-6390)
- Chase Correia (ORCID: https://orcid.org/0000-0001-9906-7093)
- Monique Hinchcliff (ORCID: https://orcid.org/0000-0002-8652-9890)
- Sarah A. Fantus (ORCID: https://orcid.org/0000-0002-1725-2349)
- Seamus Mawe
- Heather Bukiri (ORCID: https://orcid.org/0000-0002-4088-7940)
- Elizabeth Bundschuh
- Shawn E. Cowper (ORCID: https://orcid.org/0000-0002-5850-4389)
- Norman Pagé
- Nikhil Pradhan
- Lucy Duran Camacho
- Ilayda Gunes
Institutions
- Northwestern University (US)
- University of California, Los Angeles (US)
- Columbia University Irving Medical Center (US)
- Yale University (US)
- University of New Haven (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s13075-025-03508-9
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Scleroderma Research Foundation
- Sanofi
- Yale University
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences