Influence of CYP2D6 polymorphisms on tamoxifen side effects in patients with breast cancer
Uterine alterations in breast cancer patients treated with tamoxifen appear linked to decreased CYP2D6 activity, although we observed no association between CYP2D6 and other toxicities. These findings suggest closer monitoring for uterine toxicity in individuals with impaired CYP2D6 metabolism.
Authors
- Marina Linares-Rodríguez (ORCID: https://orcid.org/0000-0001-7075-1123)
- Fernando Rodríguez‐Serrano (ORCID: https://orcid.org/0000-0002-7105-4060)
- Isabel Blancas (ORCID: https://orcid.org/0000-0002-5867-6615)
- Carlos José Rodríguez-González (ORCID: https://orcid.org/0000-0002-9004-5362)
Institutions
- Universidad de Granada (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1007/s12094-025-03908-y
- Citations
- 3
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Universidad de Granada
- Consejería de Salud y Familias, Junta de Andalucía
- Junta de Andalucía