Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4
Type 2 diabetes was associated with decreased cerebral perfusion and glucose uptake but increased fatty acid uptake in white matter. The elevated fatty acid uptake observed both in individuals with type 2 diabetes and in APOE-ε4 carriers suggests a common metabolic dysfunction for these Alzheimer's disease risk factors and suggests that targeting cerebral metabolic dysfunction, particularly fatty acid metabolism, could be a potential strategy for reducing the risk for neurodegeneration in individuals with type 2 diabetes.
Authors
- Iina Laitinen (ORCID: https://orcid.org/0000-0002-1362-7625)
- Torsten Danfors (ORCID: https://orcid.org/0000-0002-2454-5086)
- Anders Gummesson (ORCID: https://orcid.org/0000-0003-0024-960X)
- Kerstin Heurling (ORCID: https://orcid.org/0000-0001-8497-9612)
- Pirjo Nuutila (ORCID: https://orcid.org/0000-0001-9597-338X)
- Martin Schain (ORCID: https://orcid.org/0000-0003-2032-4312)
- A. Frödén Löwenmark
- L. E. B. Johansson (ORCID: https://orcid.org/0000-0001-5954-3497)
- Edvin Johansson (ORCID: https://orcid.org/0000-0003-2515-2054)
- Mark Lubberink (ORCID: https://orcid.org/0000-0001-8324-7399)
- Jan Oscarsson
- Russell Esterline
Institutions
- Uppsala University (SE)
- University of Turku (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
- Antaros Medical (Sweden) (SE)
- AstraZeneca (Poland) (PL)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (Spain) (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1007/s00125-025-06405-7
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- AstraZeneca
- University of Toronto