Treatment of sperm with the Protein Digestive Enzyme Chymotrypsin Markedly Improves Sperm Rapid Linear Motion of Sperm Pre and Post Wash Allowing a Live Delivery Following Intrauterine Insemination in A Woman with Marked Diminished oocyte Reserve

Patients with sperm with the absence of sperm with rapid linear motion (RLM) after processing for intrauterine insemination (IUI) have a very poor pregnancy rate. A couple with 6 years of infertility with the female partner having a very diminished oocyte reserve (DOR) as evidenced by an undetected antimullerain hormone level was complicated by the male partner having the absence of sperm with RLM both before and after sperm wash prior to IUI. Treating the sperm before sperm wash with the protein digestive enzyme chymotrypsin not only markedly improved the RLM of the post washed sperm but resulted in a live delivery after just one IUI with enzyme treated sperm. This supports the hypothesis that at least in some cases a toxic protein possibly added as sperm traverses the ejaculatory ducts may adversely affect quality of sperm motility which can be negated by protein enzymatic neutralization of this possible toxic protein.