Somatic AKT1 Mutations May Confer Increased Risk of Preoperative Seizures in Meningiomas
Our study suggests that AKT1 mutation, high serum creatinine, and decreased age at surgery may be predictors of preoperative seizures in primary meningioma patients. In addition, prior preoperative seizures portended increased risk of postoperative seizure in this patient cohort and meningioma resection surgery was protective against the development of postoperative seizure. These analyses may improve treatment paradigms by helping to identify the patients who may benefit from earlier preoperative antiseizure medication usage.
Authors
- Rui Feng
- John W. Rutland (ORCID: https://orcid.org/0000-0002-6412-6708)
- Mehek Dedhia (ORCID: https://orcid.org/0000-0001-6579-9528)
- Corey M. Gill (ORCID: https://orcid.org/0000-0003-4494-1948)
- Jonathan T. Dullea (ORCID: https://orcid.org/0000-0002-8018-1213)
- Ai Phuong Tong (ORCID: https://orcid.org/0000-0002-2771-9504)
- Raj Shrivastava (ORCID: https://orcid.org/0000-0002-7454-8525)
- Margaret Pain
- Emily Chapman (ORCID: https://orcid.org/0000-0002-7555-2788)
- Joshua B. Bederson (ORCID: https://orcid.org/0000-0002-3676-9175)
- Ansley Unterberger
- Alex Devarajan (ORCID: https://orcid.org/0000-0002-7728-9573)
- A. D. P. Rao (ORCID: https://orcid.org/0009-0001-3041-4453)
- Emery Monnig (ORCID: https://orcid.org/0009-0007-8114-862X)
Institutions
- University of Washington (US)
- UPMC Central Pa (US)
- Washington Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1227/neu.0000000000003445
- Citations
- 1
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 1.35