TCAM-Diff: Triplane-Aware Cross-Attention Medical Diffusion Model

We introduce TCAM-Diff, a novel 3D medical image generation model that reduces the memory requirements to encode and generate high-resolution 3D data. This model utilizes a decoder-only autoencoder method to learn triplane representation from dense volume and leverages generalization operations to prevent overfitting. Subsequently, it uses a triplane-aware cross-attention diffusion model to learn and integrate these features effectively. Furthermore, the features generated by the diffusion model can be rapidly transformed into 3D volumes using a pre-trained decoder module. Our experiments on three different scales of medical datasets, BrainTumour 128x128x128, Pancreas 256x256x256, and Colon 512x512x512, demonstrated outstanding results. We utilized MSE and SSIM to evaluate reconstruction quality and leveraged the Wasserstein Generative Adversarial Network (W-GAN) critic to assess generative quality. Comparisons to existing approaches show that our method gives better reconstruction and generation results than other encoder-decoder methods with similar-sized latent spaces.