A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons
These findings suggest that baicalin enhances anterograde axoplasmic transport by upregulating KIF5A expression, facilitating vesicular trafficking and improving synaptic function in glutamatergic neurons. This study provides novel insights into the molecular mechanisms of antidepressant effects of baicalin, highlighting KIF5A as a potential therapeutic target for depression.
Authors
- Shuaifei Lu
- Changjing Zhang
- Xiangli Yan
- Baoying Wang (ORCID: https://orcid.org/0000-0002-0333-2532)
- Yucheng Li (ORCID: https://orcid.org/0000-0003-4611-8314)
- Erping Xu
- Xiaohui Jin (ORCID: https://orcid.org/0000-0002-4591-0142)
- Ji-Duo Shen
- Xianghua Liu
- Ming Bai (ORCID: https://orcid.org/0009-0003-5317-440X)
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fphar.2025.1577676
- Citations
- 1
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Henan Provincial Science and Technology Research Project